When watching Blade, one thing is clear from the start: This is a comic book character living in a comic book world, even if the world is no longer the one he originated from in Marvel’s Dracula.
What really brings this movie home to me, is a realistic, urban style that yet reminds a lot of Timothy Bradstreet’s art for Vampire: The Masquerade. Interestingly Tim then actually did work on the sequel, which, as is not unusual, goes for a much different, less realistic & urban style. You couldn’t readily tell that he was involved in the creation of the vampires for Blade II, but I would be willing to bet good money that it was Bradstreet’s illustrations made for Vampire: The Masquerade (and to a degree William Friedkin’s formidable movie French Connection) that influenced the look of the first Blade movie the most.
It’s a marvel actually that White Wolf did try to sue them, given how obvious it becomes that the art department consciously tried to recreate the RPG game's look as close as they could without outright copying it.